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KMID : 0613820100200101498
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Journal of Life Science
2010 Volume.20 No. 10 p.1498 ~ p.1504
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Identification of Polymorphisms in CAST Gene Associated with Economic Traits in Hanwoo (Bos taurus coreanae)
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Oh Jea-Don
Lee Jin-Ah
Lee Kun-Woo
Park Keong-Do
Cho Byung-Wook
Jeon Gwang-Joo
Lee Hak-Kyo
Kong Hong-Sik
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Abstract
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A number of studies have shown that the calpain system is important in normal skeletal muscle growth. An increased rate of skeletal muscle growth can result from a decreased rate of muscle protein degradation, and this is associated with a decrease in activity of the calpain system, due principally to a large increase in calpastatin (CAST) activity. The CAST gene, mapped to BTA 7, is considered a candidate gene for beef tenderness and muscle growth. The present study used comparative sequencing of five novel polymorphisms located within exon 20 and 22 of the bovine CAST gene in Hanwoo: exon20- 109737G/A, 109749T/C, 109823T/C, exon22- 116151G/A, intron- 109926G/A. The association of the CAST SNPs with economic traits was studied. The 109926G/A showed a significant effect only on the longissimus muscle area (LMA, p＜0.05) in Hanwoo. 109926G/A with the genotype GG had a significantly higher effect on LMA (75.35) than the genotype AA (69.6, p＜0.05). Also, the 116151G/A showed a significant effect only on weight at 18 months (W18, p＜0.05). 116151G/A with the genotype GG had a significantly higher effect on W18 (428.54) than the genotype AA (408.87, p＜0.05).
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KEYWORD
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Calpastatin, CAST gene, SNP, Hanwoo
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